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Clerodendrum Inerme (Cleo)

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Homeopathic Remedy Clerodendrum Inerme (Cleo)

  • The homeopathic remedy called Clerodendrum Inerme

  • Clerodendron Inerme belongs to family Verbenaceae.

  • It is available in the following potencies at 6C, 9C, 12C, 18C, 30C

  • The plant is known as the "Glory Bower" and is a shrub grown in the East and parts of Australia.

  • It is very widely distributed in tropical and subtropical regions of the world and is comprised of small trees, shrubs and herbs.

  • Different parts of this plant are traditionally claimed to be used for the treatment of cough, skin rashes boils and fever.

  • It is used for skin diseases, beriberi, asthma, and rheumatism and other conditions.

  • The plant is also to treat umbilical cord infection and for cleaning uterus in folk medicine.

  • It is considered to have antifungal properties and shows promise of being chemoprotective.

  • It also has antibacterial, hepatoprotective, anticarcinogenic, uterine and intestine stimulating properties

  • It is very widely distributed in tropical and subtropical regions of the world and is comprised of small trees, shrubs and herbs.

  • Various species of Clerodendron genus has been reported in various indigenous systems of medicine and as folk medicines.

  • There has been a tremendous interest in this plant as evidenced by the voluminous work in last few decades.

  • Clerodendrum is useful for tics in PANDAS, PANS

  • Tics

  • Tourette's Syndrome

Clinical Studies on Clerodendrum Inerme for Tics

There are two important studies on the use of Clerodendrum Inerme for tics, given below:

Intractable chronic motor tics dramatically respond to Clerodendrum inerme (L) Gaertn.

2009 Jul;24(7):887-90. doi: 10.1177/0883073808331088.
Fan PC1, Huang WJ, Chiou LC.

Abstract: Tics are characterized by involuntary, sudden, rapid, repetitive, nonrhythmic, stereotyped movements or phonic productions. Those who suffer from either motor or phonic tics, but not both, for more than 1 year are diagnosed with chronic tic disorder. Several pharmacological interventions have been proposed for the treatment of tic disorder. Dopamine D2 receptor blockers and dopamine depletors are thought to be the most effective ones clinically. However, such treatments are suboptimal in terms of effectiveness and side effects, such as body weight gain and extrapyramidal symptoms. We report on a 13-year-old girl, with chronic motor tic disorder refractory to multiple anti-tic therapies, who showed dramatic improvement and remission after taking the crude leaf extract of Clerodendrum inerme (L) Gaertn. No side effects were observed during a follow-up of more than 2 years. To the best of our knowledge, this is the first report on the anti-tic effect of Clerodendrum inerme.

Hispidulin, a constituent of Clerodendrum inerme that remitted motor tics, alleviated methamphetamine-induced hyperlocomotion without motor impairment in mice.



Previously, we found a patient with an intractable motor tic disorder that could be ameliorated by the ground leaf juice of Clerodendrum inerme (CI). Furthermore, the ethanol extract of CI leaves effectively ameliorated methamphetamine-induced hyperlocomotion (MIH) in mice, an animal model mimicking the hyper-dopaminergic status of tic disorders/Tourette syndrome, schizophrenia, or obsessive-compulsive disorder. Here, we for the first time identified a constituent able to reduce MIH from the CI ethanol extract that might represent a novel lead for the treatment of such disorders.


The ethanol extract of CI was sub-divided into n-hexane, dichloromethane, n-butanol and water fractions. Using MIH alleviation as a bioassay, active compounds were identified in these fractions using silica gel chromatography, recrystallization and proton NMR spectroscopy.


The dichloromethane and n-hexane fractions were active in the bioassay. Further subfractionation and re-crystallization resulted in an active compound that was identified to be hispidulin by proton NMR spectroscopy. Hispidulin significantly alleviated MIH in mice at doses that did not affect their spontaneous locomotor activity or performance in the rotarod test, a measure for motor coordination.


Hispidulin is a flavonoid that has been isolated from several plants and reported to have anti-oxidative, anti-inflammatory and anti-cancer activities. Here, we for the very first time found that hispidulin can also alleviate MIH at doses that did not impair motor activity, suggesting a therapeutic potential of hispidulin in hyper-dopaminergic disorders.

Tic Disorders 3 - Types of Tics
(7:39 minutes)


Tic Disorders 7 - PANDAS
(4:58 minutes)


Clerodendrum Inerme (Cleo)
Homeopathic Remedy for Tics and Tourettes
(14:02 minutes)


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